Abstract
Background and Objective: Female infertility may be attributed to several causes that are fundamentally related to the health status of women. The main objective of this project was to correlate the abundance of the microbiota in cervicovaginal fluid to infertility. Materials & Methods: A total of 36 married women who voluntarily came to the hospital in Riyadh for a routine visit participated in the study. To collect the cervicovaginal liquid, a SoftcupTM menstrual device was used by the participant; the cup was then transported in a liquid nitrogen box to the laboratory for analysis. Results: The mean vaginal pH in normal women and infertile women was 3.96 and 5.06, respectively, and the difference between the two cohorts was significant (p 5.5, is primarily composed of G. vaginalis, P. anaerobius, Mycoplasma hominis, Mobiluncus species and Atopobium vaginae. The protein content and viscosity of the cervicovaginal liquid were significantly lower in infertile women compared to normal women (p < 0.05).
Highlights
The World Health Organization estimates that approximately 8% of couples, or 50 - 80 million people worldwide, have some forms of infertility [1]
The results showed a clear correlation between the pH value and the floral species detected in the cervicovaginal liquid
Normal flora is primarily composed of a heterogeneous group of Lactobacillus species that have been detected at pH range 3.0 - 4.5, whereas a second group of bacteria mainly composed of Gardnerella vaginalis, Peptostreptococcus anaerobius and L. iners has been detected in a pH range between 4.5 and 5.5
Summary
The World Health Organization estimates that approximately 8% of couples, or 50 - 80 million people worldwide, have some forms of infertility [1]. 10% - 15% of married couples have had either primary or secondary infertility experiences [2]. This finding may be due to several causes that are fundamentally related to the healthy state of women. Some environmental factors such as smoking and alcohol consumption were linked to infertility. Female infertility may be attributed to several causes that are fundamentally related to the health status of women. The protein content and viscosity of the cervicovaginal liquid were significantly lower in infertile women compared to normal women (p < 0.05)
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