Abstract
The fragility fracture fixation confronts with the major problem of implant loosening due to the altered bone structure. Techniques used to fragility fracture stabilization includes metals devices, cements or adhesives. Different types of cements and adhesive can be obtained by chemical manipulation in order to provide a more efficient transition between the metal surface and the real bone. Thus, by selecting the appropriate chemical composition and ration between the components, synthetic cement and adhesive can provide a proper interface that ensure a perfect cohesion between the implant material and the natural bone. Most of the studies point the benefit of these synthetic materials in improving screw fixation strength. That is why, currently, the synthetic materials used in prosthesis are improved by associating with natural components of the bone, such as hydroxyapatite. For osteoporosis, which is characterized by demineralization, the association of the implanted material with hydroxyapatite is expected to be a suited solution for bone matrix regeneration after implantation. The aim of the current study was to assess the mechanical properties of orthopedic screws coated with a new polyurethane acrylate polymer containing hydroxyapatite in order to improve the stability of the screw for the subsequent fixation of the fragility fracture. To test the efficiency of the new hydroxyapatite containing polymer, the mechanical behavior of the coated screws was evaluated. Our data show that the augmented screw can be obtained by incorporating lower hydroxyapatite concentrations.
Highlights
The fragility fracture fixation confronts with the major problem of implant loosening due to the altered bone structure
The new hydroxyapatite polyurethane acrylate polymer was obtained by mixing hydroxyapatite with an aqueous solution of polyurethane acrylate which by strongly stirring generates a stable suspension of hydroxyapatite in PUA
In the case of a real bone, both acrylate polyurethane and hydroxyapatite can form a significant number of strong physical bonds with the active groups from collagen belonging to the bone matrix, promoting an intimate connection to the implant
Summary
The fragility fracture fixation confronts with the major problem of implant loosening due to the altered bone structure. The aim of the current study was to assess the mechanical properties of orthopedic screws coated with a new polyurethane acrylate polymer containing hydroxyapatite in order to improve the stability of the screw for the subsequent fixation of the fragility fracture. In our previous work [15], we had studied the improvement of the orthopedic screw fixation by covering it with a particular polyurethane, namely acrylic polyurethane (PUA). The aim of the study was to evaluate the influence of HA on implant stability using orthopedic screws coated with PUA containing different concentrations of HA. The screws coated with the new hydroxyapatite-polymers (PUA-HAs) were used to fix artificial osteoporotic bone samples and the mechanical properties of the joints were assessed. The polyurethane acrylate polymer was previous tested for the capacity to augment orthopedic screw fixation on artificial osteoporotic bone [15]. Hydroxyapatite was chosen due to its similarity to the bone structure, interfacial stability and good adhesion [16], osseointegration [17], osteoconduction [18] and osteoinduction [19]
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