Abstract
Introduction. The results of a hygienic risk assessment of the use of pesticides based on glyphosate in agricultural production are presented. The study of the pathogenetic mechanisms of action on the body of widely used glyphosate-containing herbicides and the search for markers of health conditions that change under the influence of these drugs are of increasing interest for the early diagnosis of pathological processes and the prevention of occupational and occupational diseases. The aim of this study was to assess the health effects of glyphosate-based pesticides on the health of operators in an agricultural environment. Materials and methods. The clinical material for the study was the plasma and erythrocytes of the peripheral blood of operators in contact with glyphosate-containing pesticides. As a control group, 20 clinically healthy individuals of the same age group, who had no contact with the studied pesticides, were selected. There were assessed leading indices of general clinical and biochemical blood tests and markers of endogenous intoxication and oxidative stress. Results. There were established acceptable risk of exposure to pesticides on workers, subject to compliance with technological regulations and safety requirements. Minor deviations of indicators of general and biochemical blood tests were revealed. A statistically significant increase in the total level of carbonyl derivatives compared to control was obtained among operators who had more substantial contact with glyphosate-containing pesticides. Conclusion. Working conditions when using preparations in the form of aqueous solutions containing glyphosate, using ground-based spraying of steam fields with a consumption rate of 8 l / ha, subject to compliance with regulations and safety measures, comply with hygienic requirements. The established statistically significant changes in the blood parameters of the operators in comparison with the control group indicate the presence of a risk to the health for workers in contact with glyphosate-containing pesticides and indicates the need for additional biochemical studies during periodic medical examinations of agricultural workers for the early detection of deviations in the health state caused by exposure to pesticides, including those containing glyphosate.
Highlights
The results of a hygienic risk assessment of the use of pesticides based on glyphosate in agricultural production are presented
A statistically significant increase in the total level of carbonyl derivatives compared to control was obtained among operators who had more substantial contact with glyphosate-containing pesticides
The established statistically significant changes in the blood parameters of the operators in comparison with the control group indicate the presence of a risk to the health for workers in contact with glyphosate-containing pesticides and indicates the need for additional biochemical studies during periodic medical examinations of agricultural workers for the early detection of deviations in the health state caused by exposure to pesticides, including those containing glyphosate
Summary
Мирошникова Д.И., Ракитский В.Н., Березняк И.В., Иванова Л.Г. Влияние пестицидов на основе глифосата на здоровье работников сельскохозяйственного производства. Представлены результаты гигиенической оценки риска применения пестицидов на основе глифосата в условиях сельскохозяйственного производства. Цель исследования – оценка влияния пестицидов на основе глифосата на здоровье операторов в условиях сельскохозяйственного производства. Клиническим материалом для исследования явились плазма и эритроциты периферической крови операторов, контактирующих с глифосатсодержащими пестицидами. Установленные статистически значимые изменения показателей крови операторов по сравнению с контролем свидетельствуют о наличии риска для здоровья работающих, контактирующих с глифосатсодержащими пестицидами, и необходимости дополнительных биохимических исследований при проведении периодических медицинских осмотров работников сельскохозяйственного производства для раннего выявления отклонений в состоянии здоровья, вызванных воздействием пестицидов, в том числе содержащих глифосат. Для цитирования: Мирошникова Д.И., Ракитский В.Н., Березняк И.В., Иванова Л.Г. Влияние пестицидов на основе глифосата на здоровье работников сельскохозяйственного производства. – концепция и дизайн исследования, сбор и обработка материала, статистическая обработка, написание текста; Ракитский В.Н. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, Mytishchi, 141014, Russian Federation
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