Abstract
The aim of our study was to assess in our context, the efficacy of Rifaxim in improving the symptoms of irritable bowel syndrome particularly in its diarrheal (IBS-D) or mixed (IBS-DC) component and therefore assess its impact on patients’ quality of life. Patients and methods: This was an uncontrolled, non-comparative prospective cohort study of a single group of patients. Patients recruitment was done in two University Hospitals for 6 months (September 2015-February 2016). Were included ambulatory patients, male or female, aged 18 - 75 years, with diarrheic IBS (IBS-D) or mixed IBS (IBS-DC) diagnosed according to Rome III criteria and who agreed to participate in the study. Each patient received 400mg Rifaximin × 2/d for 15 days. The overall assessment of the efficacy of treatment at D15 (end of treatment) and D30 (2 weeks post-treatment) was the primary criterion of judgment. The statistical tests used were the Chi-square test and Fisher’s exact test for the qualitative variables and Student’s test for the quantitative variables. Results: A total number of 30 patients (16 women) with an average age of 44.5 ± 13.9 years were included. The overall assessment of symptoms by the patient with the Likert scale found 28 (93.3%) patients, 12 (40%) patients and 10 patients (33.3%) for a scale ≥2 at D0, D15 and D30 respectively. The assessment of the intensity of pain or abdominal discomfort found at D0, D15 and D30 respectively: 27(90%), 13(43.4%) and 6(20.1%) patients who had an EVA score > 2. The mean score for Francis to assess the improved quality of life was 247.1 ± 97.4 at D0, 99.8 ± 63.1 at D15 and 128.8 ± 70.6 at D30. Conclusion: There is a good overall improvement of symptoms in our patients suffering from IBS-D or mixed (IBS-DC) on Rifaximin with improvement of the quality of life.
Highlights
Irritable Bowel Syndrome is a common condition
The aim of our study was to assess in our context, the efficacy of Rifaxim in improving the symptoms of irritable bowel syndrome in its diarrheal (IBS-D) or mixed (IBS-DC) component and assess its impact on patients’ quality of life
The aim of this study was to assess the efficacy of Rifaximin in improving the symptoms of irritable bowel syndrome, in its diarrheic (IBS-D) or mixed (IBS-DC) component and assess its impact on the quality of life of patients
Summary
The chronic and recurring nature of symptoms has a strong impact on patients’ quality of life. Irritable Bowel Syndrome (IBS) is a multifactorial disease, and better understanding of the pathophysiological mechanisms of IBS has led to a progressive diversification of management options. Among the possible pathophysiological approaches, more and more data highlight the role played by abnormalities of the intestinal microbiota in the onset of symptoms [2]. This evolution in the pathophysiological design of the IBS opens new therapeutic perspectives with the possible use of probiotics, prebiotics and antibiotics such as Rifaximin to improve the digestive comfort and quality of life of persons suffering from IBS [3]
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