Abstract
Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.
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