Abstract
BackgroundSacrococcygeal pilonidal sinus disease (PSD) is an infection of the skin and subcutaneous tissue at the upper part of the natal cleft of the buttocks. Excision and healing by granulation “lay-open” method is still more preferable than other methods of midline closure or using flaps but the healing time is lengthy. The present study was performed to assess the healing promotion effect of platelet-rich plasma (PRP) on the pilonidal sinus wounds treated by the lay-open method.MethodsOne hundred patients suffering from PSD were randomly divided into two groups, they were treated by the lay-open method, at General surgery department, Kafr El-Sheik University hospital, Egypt, during the period from December 2018 to December 2019. Group (A) was adopted the regular dressing postoperatively, while group (B) was treated with PRP injection into the wound at 4 and 12 postoperative days.ResultsAccelerated rate of wound healing was detected in group (B) in day 10, with a significant difference detected in days 15, 20, 25 and 30 postoperative, with a mean time of complete healing 45 ± 2.6 days in group B, while it was 57 ± 2.4 days in group A with a p-value of 0.001 which indicates considerable effect in the treated group.ConclusionsPRP injection is an effective new technique in accelerating the healing of pilonidal wound after surgery, with a significant decrease in post-operative pain, complications and an early return to work.Trial registrationretrospectively registered. Trial registration number: 12/35/1016 issued on December 2018 from the Institution Review Board at Kafr El Sheikh University. ClinicalTrials.gov identifier: NCT04430413
Highlights
Sacrococcygeal Pilonidal disease is an infection of the skin and subcutaneous tissue at the upper part of the natal cleft of the buttocks [1]
Excision and healing by granulation is still preferred for low recurrence rate (3.4%) compared with other methods (20.6%) for midline closure and (10.3%) for flap closure, but healing time is lengthy and requires frequent daily dressing with a risk of infection and delayed wound healing [5]
Platelet Rich Plasma (PRP) which contains concentrated growth factors have been reported to accelerate wound healing by 30–40% giving a satisfactory outcome in the treatment of chronic skin and soft tissue lesions by supplying large amounts of growth factors and chemokines [6]
Summary
Sacrococcygeal pilonidal sinus disease (PSD) is an infection of the skin and subcutaneous tissue at the upper part of the natal cleft of the buttocks. Sacrococcygeal Pilonidal disease is an infection of the skin and subcutaneous tissue at the upper part of the natal cleft of the buttocks [1]. Excision and healing by granulation is still preferred for low recurrence rate (3.4%) compared with other methods (20.6%) for midline closure and (10.3%) for flap closure, but healing time is lengthy and requires frequent daily dressing with a risk of infection and delayed wound healing [5]. Platelet Rich Plasma (PRP) which contains concentrated growth factors have been reported to accelerate wound healing by 30–40% giving a satisfactory outcome in the treatment of chronic skin and soft tissue lesions by supplying large amounts of growth factors and chemokines [6]. This study aims to evaluate the potential of PRP therapy for accelerating the healing of pilonidal sinus wounds
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