Abstract
We analyzed three hundred and eight CSF samples belonging to 175 patients, 57% male, with a median age of 46 years (1-70 years) were analyzed. Diagnoses were acute B lymphoblastic leukemia (B-ALL, 84%), acute T lymphoblastic leukemia (T-ALL 5%), acute myeloblastic leukemia (AML, 11%). The immunophenotype was performed with an 8-color panel adapted to the diagnosis. The proportion of non-assessable CSF samples in LA was higher for CC (46%) than FCM (4%) (p<0.05). Overall, infiltration was found in 78/308 samples by FCM (25.3%) and in 8/77 by CC (10.4%) (p<0.0001). Seventy of 259 samples were positive in B-ALL (27%) and 6/34 in AML (17%). There were no CC+ cases in AML or T-ALL. The samples that were FCM+/CC+ had more significant infiltration (59.5%) than CMF+/CC-ones (30%) (p<0.0001). CMF detects more than twice as many CSF blast-positive cases in LA as CC and is, therefore, suitable for routine use along with CC.
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