Abstract
Cancer chemotherapies may result in resistance, and therefore, contemporary treatments including natural products may find an increasing consideration. As per Persian medicine (PM), many natural products have been used for malignant and chronic diseases. Triphala, with a combination of Terminalia chebula Retz., Terminalia bellirica Retz., Phyllanthus emblica L., and honey, is a multi-ingredient traditional formulation attributed to anticancer activities in PM. This study is aimed at evaluating the cytotoxic activity of this preparation on HepG2, the human liver cancer cell line. Hydroalcoholic extracts were prepared from the formulation and its components. Compared with the control and Cisplatin, the extracts were tested using MTT assay at different concentrations. All concentrations of the preparation, as well as Cisplatin, were effective significantly against HepG2 cells. All extract preparations at multiple concentrations were significantly effective as evidenced by MTT assay when compared to the control group. The IC50 level for Triphala extract was 77.63 ± 4.3 μg/ml. Based on the results, Triphala and its components have cytotoxic activity on the HepG2 cancer cell line and they can reduce the survival rate significantly.
Highlights
In developed and developing countries, one of the main causes of death is cancer
Persian medicine (PM), as one of the well-known and developed sections of complementary medicine, has introduced medicines derived from medicinal plants for the treatment of various diseases [4]
The formulation of Triphala is composed of the above ingredients in a ratio of 1 : 1 : 1. After weighing the milled samples, they were mixed in the desired ratio so that the final weight of the resulting powder was 1 kg, and Triphala was prepared in the form of a semisolid oral formulation by adding honey equal to the weight of the entire powder
Summary
In developed and developing countries, one of the main causes of death is cancer. Cancer is the abnormal growth of human cells and is a factor to interfere with human healthy and functional cell lines. The occurrence of cancer is mainly due to imbalances in many organs and requires huge control costs yearly [1]. In addition to expensive costs and lack of widespread and available cancer drugs, many side effects have been reported for these medicines [2]. The role of medicinal plants as an alternative or adjuvant therapy to conventional drugs in the control and prevention of cancer and related complications has received widespread attention [3]. Documents and reports of complementary medicine around the world are valuable for new drug discovery and management of various diseases. Persian medicine (PM), as one of the well-known and developed sections of complementary medicine, has introduced medicines derived from medicinal plants for the treatment of various diseases [4]
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