Abstract
Background: Dynamic contrast-enhanced computed tomography (DCE-CT) is a promising non-invasive method that provides the functional evaluation of the vascularity in normal and malignant tissue. The objectives of this consecutive study were to investigate the possible correlation between the perfusion characteristics of colorectal cancer liver metastases as examined by (DCE-CT) and the microvessel density of resected metastases. An additional aim was to investigate the correlation between the urokinase plasminogen activation receptor (uPAR) and perfusion values. Methods and findings: Eleven patients fulfilled the criteria for comparative analyses. The microvessel density values,uPAR level and the DCE-CT values were analysed. A perfusion index (PI) based on the measurement of arterial and portal flow (AF, PF) was defined as follows: PI=AF/ (AF+PF)%. The DCE-CT measurements were compared between metastatic and normal liver tissues. A Spearman correlation test was used for statistical analysis. The perfusion index and microvessel density values were significantly correlated (r=0.75; p=0.01). Furthermore, a higher volume of metastases significantly correlated with higher plasma levels of the uPAR forms (0.72 ≤ r ≥ 0.89; p < 0.05). Conclusions: DCE-CT may have the potential to measure the vascularity of colorectal liver metastases; however, the correlation between microvessel density and the perfusion values appears vague.
Highlights
Advanced colorectal cancer shows a poor prognosis, and more than 50% of patients develop metastases, most frequently in the liver, during their disease course [1,2]
Eight patients were excluded due to no detectable metastases at the Dynamic contrast-enhanced computed tomography (DCE-CT) examination, resulting in 11 patients were included for the analyses of DCE-CT values, urokinase plasminogen activator receptor (uPAR) and microvessel density (FIGURE 1)
DCE-CT values, microvessel density and uPAR were evaluated in 11 patients diagnosed with histologically proven colorectal liver metastases
Summary
Advanced colorectal cancer shows a poor prognosis, and more than 50% of patients develop metastases, most frequently in the liver, during their disease course [1,2]. Conventional CT scans are currently the most commonly used imaging modality for monitoring malignant tissue using the RECIST criteria (response evaluation criteria in solid tumours) [14]. Dynamic contrast-enhanced computed tomography (DCE-CT) is a promising noninvasive method that provides the functional evaluation of the vascularity in normal and malignant tissue. The objectives of this consecutive study were to investigate the possible correlation between the perfusion characteristics of colorectal cancer liver metastases as examined by (DCE-CT) and the microvessel density of resected metastases. An additional aim was to investigate the correlation between the urokinase plasminogen activation receptor (uPAR) and perfusion values
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