Assessment of the biological effect of Cu nanoparticles impregnated in polyethylene medical devices combined with the effect of LED radiation of the red and violet spectra on the ability of microorganisms to form biofilms and on daily biofilms

M M Mishyna,O V Hopta,V L Avramenko,Y R Mozgova,O S Dubovyk,V O Makarov,Yu M Mishyn,G O Syrova,S G Malanchuk,I A Marchenko

doi:10.12775/jehs.2021.11.02.014

Abstract

For many years scientists around the world have been looking for an alternative to antibiotics due to rapidly growing level of resistance to them. LED light of various spectra and metal nanoparticles are considered as a promising alternative to antibiotics. In this work, we determined the complex effect of copper nanoparticles impregnated in high-pressure polyethylene and non-woven material with the effect of red and violet LED radiation on the ability of microorganisms to form biofilms and on already formed daily biofilms.

Highlights

Today the question of finding new compounds with pronounced antimicrobial activity is relevant, which is associated with the ever-increasing resistance of causative agents of purulent-inflammatory diseases to existing antimicrobial drugs
A group of scientists conducted an experiment in vivo on mice simulating burns and infection with a multidrug-resistant strain of Acinetobacter baumannii, the lesion focus was irradiated with blue light for 30 minutes and a decrease in bacterial load was determined as well as it was found that after 10 cycles of inactivation with blue spectrum of LED radiation bacteria progressed no resistance [6]
Similar results were obtained by the same scientists in the study of S.aureus-MRSA localized infection in vivo: blue light contributed to the rapid rate of bacterial load reduction, growth recovery was observed a day after irradiation [7] which requires further research to determine the feasibility of using LED radiation of different spectra in localized purulent-inflammatory lesions

Summary

Introduction

Today the question of finding new compounds with pronounced antimicrobial activity is relevant, which is associated with the ever-increasing resistance of causative agents of purulent-inflammatory diseases to existing antimicrobial drugs.

Results

Conclusion