Assessment of the arginine and glutamic acid content in the blood serum of full-term newborns with intrauterine growth retardation

Abstract

The problem of intrauterine growth retardation is currently relevant, as it is one of the causes of neonatal morbidity and mortality. Purpose. To study the course of the neonatal period and evaluate the content of arginine and glutamic acid in full-term newborns depending on the severity of intrauterine growth retardation.Material and methods. 78 full-term newborns with intrauterine growth retardation according to hypotrophic type were examined. The content of glutamic acid and arginine in blood serum was determined in the early neonatal period by capillary electrophoresis using an unmodified quartz capillary (Kapel-105, Lumeks, St. Petersburg, Russia).Results. Markers of the formation of a severe degree of intrauterine growth retardation were identified: increased levels of glutamic acid and arginine, taking into account impaired cerebral blood flow in the early neonatal period. A model is proposed for predicting the persistence of a severe degree of intrauterine growth retardation in newborns by the end of the neonatal period.Conclusion. The proposed diagnostic criteria make it possible to start specific therapy in a timely manner in order to prevent the formation of a severe degree of intrauterine growth retardation.