Abstract
The aim of this study was to demonstrate that caffeic acid, an antioxidant with phenolic structure, can improve the antioxidant status of retinal pigment epithelium (RPE), when oxidative stress is induced by high glucose concentrations in culture medium. We evaluate the high glucose and caffeic acid cytotoxicity and their action on retinal pigmented epithelial cell viability, intracellular reactive oxygen species generation, superoxid dismutase and gluthatione reductase activity. Caffeic acid did not show any cytotoxic effect on RPE cells up to 250 μM in culture medium and protect them against induced oxidation. Caffeic acid protects RPE cells by quenching the intracellular ROS generation and by enhancing the activity of glutathione peroxidase and superoxide dismutase. Caffeic acid treatment of cultured RPE cells can contribute to antioxidant defence in oxidative stress conditions induced by hyperglycaemia
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