Abstract
The increasing human exposure to dichlorvos (DDVP) and its toxicity is a growing public health concern. This work was aimed at studying the therapeutic effect of Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare extracts against DDVP induced hepatotoxicity in rats. Total of 50 male adult rats of average weight 272g were placed in ten groups (n=5) and orally administered normal saline (normal control), 8.0mg/kg body weight DDVP (positive control), 8.0mg/kg body weight DDVP + 200mg/kg and 400mg/kg body weight of the plant extracts and 20 mg/kg body weight and 40 mg/kg bodyweight of vitamin C for 28 days. DDVP significantly (P<0.05) increased Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and Gamma glutamyl transferase (GGT) when compared with normal control. Treatment with aqueous leaf extracts of Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare significantly reversed the distortions in the values of biochemical parameters when compared with positive control. Photomicrographs obtained from histological examination of liver tissues corroborate these findings. Aqueous leaf extracts of Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare may have therapeutic potentials to DDVP induced hepatotoxicity in rats.
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