Abstract
The primordial follicles are formed by an oocyte arrested in meiosis surrounded by a layer of flattened cells called granulosa cells (GCs). During follicular development to preantral stage, GCs acquire a cuboidal shape and proliferate forming multiple layers, ensuring oocyte maturation, mediated by a cross-talk between the two cell types. Interestingly, these somatic cells have some common characteristics with stem cells, such as long telomeres and telomerase activity, which will ensure the potential for multiple divisions. The aim of this work is to evaluate telomere maintenance of GCs short-term culture in two different media (A199 and DMEM), and the effects of follicular fluid (FF), which contains estrogens, known telomerase activators.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
