Abstract
Introduction: Sleep bruxism (SB) is a widespread masticatory muscle activity during sleep and affects approximately 13.2% of the general population. Telomerase reverse transcriptase (TERT) plays a role in preventing the shortening of the telomere. This prospective, observational study aimed to investigate the relationship between single nucleotide polymorphism (SNP) of TERT and the severity of SB and to identify the independent risk factors for SB. Methods: A total of 112 patients were diagnosed by performing one-night polysomnography based on the guidelines of the American Academy of Sleep Medicine. TERT SNP was detected by real-time quantitative polymerase chain reaction (qPCR). Results: Statistical analysis showed the lack of relationship between the rs2853669 polymorphism of TERT and severity of SB (p > 0.05). However, the study showed that patients with allele T in the 2736100 polymorphism of TERT had a lower score on the phasic bruxism episode index (BEI). Based on the receiver operating characteristic (ROC) curve, the value of phasic BEI was 0.8 for the differential prediction for the presence of allele T in the locus. The sensitivity and specificity were 0.328 and 0.893, respectively. The regression analysis showed that lack of TERT rs2736100 T allele, male gender, and arterial hypertension are the risk factors for the higher value of phasic BEI. Conclusion: The SNP of the TERT gene affects phasic SB intensity. The absence of TERT rs2736100 T allele, male sex, and arterial hypertension are independent risk factors for phasic SB.
Highlights
Introduction published maps and institutional affilThe widely accepted international consensus by Lobbezoo et al defines sleep bruxism (SB) as a “masticatory muscle activity during sleep that is characterized as rhythmic or nonrhythmic and is not a movement disorder or a sleep disorder in otherwise healthy individuals” [1]
The present study aimed to investigate the relationship between single nucleotide polymorphism (SNP) of the Telomerase reverse transcriptase (TERT) gene and the severity of Sleep bruxism (SB) and to identify the independent risk factors for SB
The selection of the investigated SNPs in the TERT gene was based on the results from the SNP Function Prediction tool of the National Institute of Environmental Health Sciences (NCBI Database) website and other auxiliary databases
Summary
The widely accepted international consensus by Lobbezoo et al defines sleep bruxism (SB) as a “masticatory muscle activity during sleep that is characterized as rhythmic (phasic) or nonrhythmic (tonic) and is not a movement disorder or a sleep disorder in otherwise healthy individuals” [1]. The pathogenesis of SB is complex and not fully understood. Polymorphism of dopamine and serotonin receptor genes, dysfunction of the autonomic nervous system [6,7], hypertension [8], and airway obstruction [9] are associated with the pathogenesis of SB [10]. A recent study showed that SB is associated with systemic inflammation [11], which has been shown to affect telomere length [12].
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