Assessment of Systemic Immune-inflammation Index Levels in Patients with Retinal Vein Occlusion

Abstract

ABSTRACT Purpose To assess the predictive value of inflammatory markers calculated from complete blood counts in patients with retinal vein occlusion (RVO). Methods This was a retrospective cross-sectional study with a total of 56 RVO patients and 56 age- and gender-matched controls involved. All subjects went through a routine ocular examination, and the peripheral venous blood samples were collected to analyze the differences in inflammatory markers between groups. Results The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) values were significantly higher in RVO patients than those in the controls (p=0.002, p=0.004, respectively). According to the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUC) of SII was 0.666. The AUC of NLR was 0.657. Conclusion As a novel inflammatory indicator, SII is a more promising indicator than NLR and PLR in the prediction of RVO development.