Abstract
4556 Background: Despite having different staging systems, is unclear whether or not distal esophageal (DE) and gastric cardia (GC) tumors should be treated similarly (due to comparable biology) or differently (due to dissimilar biology). We hypothesized that tumor location (gastric body or fundus [GBF], GC, DE, and mid-thoracic esophagus [MTE]) has a significant influence on overall survival. Methods: Using the Surveillance Epidemiology and End Results database, we identified 41,143 patients who were diagnosed with invasive MTE (n=8,607), DE (n=12,694), GC (n=13,296) or GBF (n=6,546) carcinomas from 1973 through 2003 and evaluated them for differences in overall survival, by their tumor location. In order to adjust our survival analysis for potential confounding variables (histology, stage, race, cancer directed surgery, and radiation therapy), we utilized a Cox proportional hazards regression model (α=.05). Results: After adjusting for tumor location, histology, stage, race, cancer directed surgery, and...
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