Abstract
A lot of anti-malarial drugs are known to have serious detrimental effects on the sperm indices in experimental animals as well as in man; although recently, some drugs have been shown to have no adverse effects on testicular functions. The dearth of information on the reproductive toxicity of Trichilia monadelpha, a potent antimalarial plant in West Africa, especially in the South Western part of Nigeria, makes this study important. The effects of the aqueous extract of T. monadelpha were studied on sperm motility, viability and counts and serum concentration of testosterone in male albino rats. Oral administration of 400 mg/kg/day of T. monadelpha stem extract was administered for 4 weeks. The control rats received the vehicle, and all treated rats had corresponding recovery groups. There was a significant increase in sperm motility and viability (P 0.05) and there was a decrease in the serum testosterone level at P < 0.01. The results suggested that the administration of T. monadelpha at a dose of 400 mg/kg/day that was employed in this study had no adverse effects on testicular functions in the rat. Key words: Anti-malarial drugs, aqueous extract, sperm quality, testosterone, male rat.
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