Abstract

Sperm chromatin structure is of vital importance for successful embryo growth. The fertility potential of an ejaculate is considered impaired if >27–30% of sperm have DNA fragmentation. Cancer patients often resort to sperm cryopreservation for fertility preservation. It is imperative to evaluate the sperm chromatin in these cryopreserved specimens prior to their use in ART. The sperm chromatin structure assay (SCSA) is a standardized method that assesses fragmented sperm DNA (DNA Fragmentation Index, %DFI) and immature chromatin (High DNA Stainability Index, %HDS).

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