Assessment of some Immunological Parameters in Sera of Hepatitis C Virus Infected Patients in Babylon – Iraq

Abstract

In developing nations, the major cause for liver infection that lead to liver fibrosis and cancer is the virus type C. The research has been conducted on 800 individuals assumed to be infected with hepatitis C virus, those individuals have been admitted to AL-Hilla Teaching Hospital ,Central Public Health laboratory, to the possible relation of serum interferon -α, CD56, IL-10 and IL-12 in case infection of virus type C comparison to normal healthy control groups. ELISA assay was used for detection antibodies to hepatitis C virus antigen as well as its immunological response in the subjects which were infected. The result indicated that just 40 from 800 individuals (12-62) years old had HCV positive which represent (5.2%) with high frequency in male( 67.3%/), than female(32.6%) groups . The study also show elevated of IL-10 level in all groups of patients compared to the groups of normal healthy controls (P0.05). The highest level was reached to 81.61pg/ml and 90.69pg/ml in male and female respectively. The IL-12 level also revealed a significant increase level in all groups of patients compared to the group of normal healthy controls (P0.05). The highest level for it was reached to 99.25 pg/ml and 125.33pg/ml in male and female respectively. The study also revealed enhancement of IFN- α levels in all groups of patients compared to the groups of normal healthy controls (P0.05) the higher level which was 201.69 pg/ml and 311.71pg/ml male and female respectively. The results also shows increase level of CD56 in all groups of patients compared to the group of normal healthy controls (P0.05). The highest level was reached to 27.984ng/ml and 30.190ng/ml in male and female respectively