Abstract

The outbreak of the novel coronavirus disease 2019 (COVID-19) occurred all over the world between 2019 and 2020. The first case of COVID-19 was reported in December 2019 in Wuhan, China. Since then, there have been more than 21 million incidences and 761 thousand casualties worldwide as of 16 August 2020. One of the epidemiological characteristics of COVID-19 is that its symptoms and fatality rates vary with the ages of the infected individuals. This study aims at assessing the impact of social distancing on the reduction of COVID-19 infected cases by constructing a mathematical model and using epidemiological data of incidences in Korea. We developed an age-structured mathematical model for describing the age-dependent dynamics of the spread of COVID-19 in Korea. We estimated the model parameters and computed the reproduction number using the actual epidemiological data reported from 1 February to 15 June 2020. We then divided the data into seven distinct periods depending on the intensity of social distancing implemented by the Korean government. By using a contact matrix to describe the contact patterns between ages, we investigated the potential effect of social distancing under various scenarios. We discovered that when the intensity of social distancing is reduced, the number of COVID-19 cases increases; the number of incidences among the age groups of people 60 and above increases significantly more than that of the age groups below the age of 60. This significant increase among the elderly groups poses a severe threat to public health because the incidence of severe cases and fatality rates of the elderly group are much higher than those of the younger groups. Therefore, it is necessary to maintain strict social distancing rules to reduce infected cases.

Highlights

  • Coronavirus Disease 2019 (COVID-19) is a novel viral disease that is currently threatening public health worldwide

  • To take these aspects into account, we developed an age-structured model that describes the age-dependent dynamics of COVID-19

  • Since the control policies implemented by the governmental authorities affect the dynamics of infectious diseases [13,35], we divided the whole period between 1 February and 15 June into seven distinct periods following important changes in governmental control policies

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Summary

Introduction

Coronavirus Disease 2019 (COVID-19) is a novel viral disease that is currently threatening public health worldwide. The virus responsible for the disease was initially called Novel Coronavirus (2019-nCoV) due to its novelty. Analysis of the phylogeny and taxonomy of 2019-nCoV have shown that the virus belongs to the subgenus Sarbecovirus, which SARS-CoV belongs to [1], but is more closely related to bat SARS-CoV [2,3]. 2019-nCoV was named “severe acute respiratory syndrome coronavirus 2” or “SARS-CoV-2” [4]. Cases of SARS-CoV-2 display symptoms such as fever, dry cough, dyspnea, and diarrhea, which are similar to symptoms noted in MERS-CoV and SARS-CoV. The distribution of each symptom differs [5]

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