Abstract
ObjectivesTo assess the sleep quality of patients with Parkinson's disease (PD) and evaluate the effect of cardiopulmonary coupling (CPC) analysis on sleep quality and its correlation with subjective complaints in patients with PD.MethodsOur study included 42 patients with PD and 30 healthy controls. CPC analysis and the Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the sleep quality of subjects.ResultsHigh‐frequency coupling (HFC) and sleep efficiency were significantly lower in the PD than in the control group, whereas very low‐frequency coupling (VLFC) and sleep latency were significantly higher in the PD than in the control group. PSQI scores were significantly higher in the PD than in the control group (all p < .05). The PSQI score showed a negative correlation with the HFC ratio in the PD group (r = −.478, p = .001). Factors related to the occurrence of PD with poor sleep quality were the unified Parkinson's disease rating scale (UPDRS) score and nocturia.ConclusionsThe sleep quality of patients with PD was generally decreased. CPC analysis can reflect the subjective sleep quality of patients with PD and serve as an effective sleep monitoring tool.
Highlights
Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting middle-aged populations
The Pittsburgh Sleep Quality Index (PSQI) score showed a negative correlation with the High-frequency coupling (HFC) ratio (r = −.478, p = .001) (Figure 3) no significant correlation was observed between the LFC and very low-frequency coupling (VLFC) (r = .057, p = .719 and r = .193, p = .220, respectively) in the PD group
Our study showed a poor overall sleep quality in patients with PD based on both, cardiopulmonary coupling (CPC) analysis and PSQI scores
Summary
Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting middle-aged populations. It is estimated that the number of patients with PD worldwide will exceed 10 million by 2030 (Dorsey et al, 2007). PD typically presents clinically with a distal resting tremor, rigidity, bradykinesia, and postural disturbances. Sleep disorders, which include insomnia, sleep apnea, excessive daytime sleepiness, and rapid eye movement sleep behavior disorder, are common in patients with PD and show a prevalence of 40–98%. A study spanning 8 years demonstrated that >50% of patients with PD reported insomnia (Gjerstad, Wentzel-Larsen, Aarsland, & Larsen, 2007). Sleep disorders seriously affect the quality of life in patients with PD
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