Abstract
Background: Sewage workers, who maintain the sewage system and provide an essential service for public health protection, may come in direct contact with sewage hazards, which then may induce DNA damage and oxidative stress. The aim of this study is to assess the level of nitric oxide, homocysteine, 8-OHdG, and vitamins A & E in the plasma of sewage workers for different periods of exposure. Results: Nitric oxide, vitamin A, and vitamin E showed significant reduction in sewage workers when compared with a non-exposed control group. However, homocysteine and 8-OHdG levels were increased in sewage workers when compared with the non-exposed control group. Conclusions: Sewage workers are exposed, through different pathways, to a variety of toxicants that cause an increase in homocysteine. Homocysteine, in turn, increased the DNA oxidative damage by increasing the concentration of 8-OHdG and decreasing nitric oxide and vitamins E & A through a decrease in the antioxidant and an increase in oxidative damage. Key words: sewage hazards, nitric oxide, homocysteine, 8-OHdG, vitamins E & A
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.