Assessment of Serum Resistin: A Recently Identified Adipocyte-Derived Hormone in Obese and Lean Individuals

Abstract

Background Due to the alarming rate at which obesity is increasing a global epidemic has been declared. Resistin one of the rodents cysteine-rich protein classes suggests that these adipocytokines could contribute to the molecular causes of obesity. Our ability to grasp this concept could be crucial in the development of novel therapies for conditions associated with obesity.Aim To investigate the connection between obese participants serum resistin levels and body mass index BMIMethods Using an ELISA kit the serum resistin levels of 15 obese persons aged 25plusmn10 years with a BMI score of 30plusmn5 and 15 lean individuals in the same age group with a BMI score of 20plusmn2 were investigated. Evaluations were also conducted on serum glucose and lipid profile markers such as cholesterol low-density lipoproteins LDL and high-density lipoproteins HDL.Results No statistical significance in serum resistin levels was noted between obese and lean individuals. Serum resistin showed a positive correlation 0.11 with HDL but yielded a negative correlation -0.263 with LDL Very-low-density lipoprotein VLDL and BMI. Independent Samples Test for HDL LDL VLDL and BMI between obese and lean showed a very high statistical significance p lt0.0001. Though serum resistin levels remained high in obese it was not significant p-value 0.078.Conclusion Although an overt rise in obesity could not be seen the concentration of circulating resistin in obese people revealed a correlation with HDL and anthropometric factors. In summary the precise role that human resistin plays in obesity insulin resistance and the onset of diabetes is still up for debate. In the near future the precise role of the intriguing new hormone resistin in metabolism will become clear.