Assessment of Serum Nitric Oxide and Some Essential Trace Elements Levels in Patients of Multiple Myeloma

Abstract

Background and objective Multiple myeloma is the most common malignant plasma cell dyscrasia and ranks second among primary haematological malignancies. The principle goal of this study was to evaluate the effect of serum essential Trace elements such as: levels of copper (Cu), zinc (Zn), selenium (Se) and molybdenum (Mo) in serum of patients with Multiple Myeloma and compared to healthy individuals Material and Methods The studied consist of 100 volunteers with age range 40-65 years, 50 healthy individuals compared with 50 patients with in order to investigate the following serum parameters: nitric oxide and some essential Trace elements (copper, zinc, selenium, and molybdenum) and compared to healthy individuals. NO levels were determined spectrophotometrically using the Griess reaction method. The serum levels of copper (Cu), zinc (Zn), selenium (Se) and molybdenum (Mo) were established using Flame Atomic Absorption Spectrometry. Results The results of this study showed significant increase in the level of nitric oxide (p Conclusion Estimation of nitric oxide and essential Trace elements may aid in diagnosis, assessment of severity and monitoring of : Multiple Myeloma (MM) Key Words: Nitric Oxide; Multiple Myeloma; Essential Trace elements