Assessment of Serum Levels of Free Tri-iodothyronine, Free Thyroxine and Thyroid Stimulating Hormone in Patients with Acne Vulgaris

Abstract

The aim of the study was to assess serum levels of free tri-iodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in patients with acne vulgaris and apparently healthy subjects, to compare all the above-mentioned parameters between the two groups and to correlate severity of acne vulgaris with serum levels of free tri-iodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH). A total number of 120 participants of both genders were selected with age ranged from 15 to 45 years based on inclusion and exclusion criteria. Among them, 60 subjects with acne vulgaris were considered as Group A who were further sub grouped into mild, moderate and severe according to severity. Sixty age matched apparently healthy subjects were included in Group B for comparison. The level of serum free tri-iodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were estimated. The study revealed significant lower levels of FT4 (p-0.02) and significant higher levels of TSH (p <0.001) of group A when compared with group B. The difference of FT3 level between group A and group B was not statistically significant (p-0.343). FT3, FT4 and TSH were positively correlated with the severity of the acne but statistically not significant.