Abstract
Background: Genital warts (GWs) are highly prevalent sexually transmitted viral illnesses that are most prevalent in young, sexually active people of both sexes. Human papillomaviruses (HPV) cause GWs. The cytokine IL-33, an IL-1 family member, stimulates immune cells necessary for type 2 immune reactions. Immune cells like CD8+ T lymphocytes, neutrophils, and macrophages, Th1 cells, and B cells, and natural killer cells that are engaged in type-1 immunity, infection, and chronic inflammation are activated in part by IL-33. Aim: This study aims to examine whether there is a difference in levels of serum IL-33 between genital warts patients and healthy controls and its correlation with genital warts' characteristics. Subjects and Methods: Levels of serum IL-33 were assessed in 40 patients with GWs and 40 healthy control persons using enzyme-linked immune-sorbent assay kits. Results: Levels of serum IL-33 were significantly lower among patients with GWs compared to the control group (p= <.001). Patients with recurrent warts had slightly lower levels of these substances. Additionally, a modest inverse relationship between the quantity of warts and levels of serum IL-33 was found. Conclusion: patients with genital warts had considerably lower levels of serum IL-33 than normal controls. 
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