Abstract
BackgroundIrisin is a newly discovered myokin secreted by myocytes responsible for transmission of signals from muscles to other body tissues. Irisin improves systemic metabolism by increasing the energy expenditure. Owing to numerous similarities in action between irisin and thyroid hormones it seems imperative to explore these substances’ potential mutual influence on the body.ObjectiveTo estimate serum irisin concentration in patients with hypothyroid and hyperthyroid diseases, and to detect the relation of serum irisin in patients with thyroid disorders with creatine kinase (CK), a serum marker of muscle damage.Patients and methodsThe study comprised 30 hyperthyroid patients (group 1), 30 hypothyroid patients (group 2), and 30 normal persons (group 3). Irisin was measured using enzymelinked immunosorbent assay. Thyroid-stimulating hormone, triiodothyronine, and free thyroxine levels were measured using chemiluminescent microparticle immunoassay technology.ResultsIrisin hormone level significantly decreased in hypothyroid patients in comparison with hyperthyroid patients. Irisin hormone level increased in hyperthyroid patients in comparison with normal persons, whereas it decreased in hypothyroid patients in comparison with normal persons. CK level significantly decreased in hyperthyroid patients in comparison with hypothyroid patients. CK level significantly increased in hypothyroid patients in comparison with normal persons, whereas it significantly decreased in hyperthyroid patients in comparison with normal persons.ConclusionObtained results suggest the influence of thermometabolic state on irisin level.
Highlights
Myokines are defined as cytokines or other peptides that are produced, expressed, and released by muscle fibers and that exert endocrine effects [1].Irisin is a hormone induced with exercise from the skeletal muscles in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure with no changes in the movement or food intake
Irisin have a significant influence on the body metabolism and thermogensis by acting on adipose tissue and promoting a phenomenon called white adipose tissue browning
Obtained results suggest the influence of thermometabolic state on irisin concentration
Summary
Irisin is a hormone induced with exercise from the skeletal muscles in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure with no changes in the movement or food intake. This results in improvements in obesity and glucose homeostasis [1]. Irisin have a significant influence on the body metabolism and thermogensis by acting on adipose tissue and promoting a phenomenon called white adipose tissue browning. White adipose tissue is the primary site of triglycerides storage, brown adipose tissue is specialized in energy expenditure to maintain body temperature in a cold environment. Owing to numerous similarities in action between irisin and thyroid hormones it seems imperative to explore these substances’ potential mutual influence on the body
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
