Assessment of Serum Cathepsin k and Lipid Profile in Chronic Coronary Syndrome Patients

Abstract

Abstract Background: The most affected public illness around the world in both industrialized and unindustrialized countries is chronic coronary syndrome (CCS). In a medical context, the measurement of lipid profile in the blood is considered as one of the most common diagnostic techniques. In addition, there is a correlation between increased level of cathepsin k (CatK) and CCS, and thus cathepsin is considered a useful biomarker for CCS. Objective: For the assessment of CatK, triglyceride (TG), cholesterol, low density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high density lipoprotein (HDL) level and to examine the probable relation of them with CCS in Babylon province. Materials and Methods: CatK, TG, cholesterol, LDL, VLDL, and HDL were estimated in 100 subjects; 50 patients with CCS and 50 healthy subjects participated in this study. Patients and control groups with an age ranged above 40 years. The CatK level was assessed by sandwich-ELISA technique whereas the level of TG, cholesterol, and HDL was assessed in serum by enzymatic colorimetric method. Also, cholesterol-LDL was measured by using Friedewald equation. Results: Serum level of CatK displayed a significant increase in CCS patients (P ≤ 0.01) compared with control group, whereas serum cholesterol-HDL level significantly decreased (P = 0.001). Also serum levels of cholesterol and cholesterol-LDL a significant increase (P ≤ 0.001), (P = 0.00) compared with control group. In contrast, the current study observed non-significant change in serum TG and VLDL (P = 0.45), (P = 0.71) respectively in CCS patients. Conclusion: Circulating CatK is a good biomarker for CCS disorders and that higher levels of CatK and lipid profile are closely related to the presence of CCS among CCS patients.