Assessment of segmental lung involvement in covid-19 patients using biochemical parameters

Abstract

This study is to investigate the segmental involvement of lung in COVID-19 individuals using high resolution computed tomography (HRCT) and to correlate with serum inflammatory markers. Retrospective study done in 100 COVID 19 RTPCR positive patients with radiological images were collected and analyzed for lobar involvement, bronchopulmonary segments in 3D and CT Scores and it was compared with serum inflammatory markers (SIM). Variables like gender, involvement of segments and co-morbid conditions were summarized as frequency and percentage. Sub group analysis was done using independent t test, Chi-Square. Findings revealed that males were commonly affected than females with the mean age 57.47 ± 13.0. Lower lobes and posterior basal segment of both the lungs were affected with preponderance on the left side. Additionally, SIM were up regulated in the COVID-19 individuals. Serum IL-6, D-dimer and Ferritin showed upsurge in right lung and CRP and LDH elevated in left lung in the COVID-19 and it was statistically correlated with CT severity score. Chest HRCT and biochemical parameters individually and in combination help in identifying the COVID 19 severity among individuals for preventing or reducing the mortality rate in adults.