Abstract
Background and Objectives: Chronic kidney disease (CKD) is an important public health problem associated with, e.g., progressive renal insufficiency, bone mineral disorders, and increased inflammatory marker levels. The objective of this study was to compare selected biochemical parameters and to evaluate potential correlations between selected anthropometric parameters and levels of sclerostin and interleukin 6 (IL-6) in blood plasma. Materials and Methods: The study group consisted of 34 patients aged 59.8 ± 9.8 years, receiving hemodialysis therapy. The control group consisted of 31 individuals aged 55.4 ± 9.37 years, presenting with GFR (glomerular filtration rate) of more than 60 mL/min/1.73 m2. Selected anthropometric and biochemical parameters were assessed at baseline, as well as 3 and 6 months into the study. Statistical analyses were performed using the Statistica 2014 software package (StatSoft, Inc.Tulsa, OK, USA). Analyses included descriptive statistics, intergroup comparisons using the Mann-Whitney U-test or the Kruskal-Wallis test, and Spearman’s correlation analysis. The significance level was set at p ≤ 0.005. Results: At all measurement time points, i.e., at baseline, at month 3, and at month 6, the IL-6 levels in the study group were significantly higher than those in the control group. No correlations were observed in the study group between SCL or IL-6 levels and anthropometric parameters such as body weight, body mass index (BMI), or waist circumference. Conclusions: Patients receiving hemodialysis replacement therapy present with significantly higher levels of IL-6 in their blood. Anthropometric parameters (body weight, BMI, and waist circumference) have no impact on sclerostin and IL-6 levels in patients undergoing hemodialysis therapy. The results obtained are satisfactory, and the research will be continued.
Highlights
Chronic kidney disease (CKD) is classified, along with arterial hypertension, cardiovascular disorders, diabetes, and obesity, as one of the lifestyle diseases, which pose significant problems to public health [1]
The study group and the control group were compared in terms of sclerostin levels (SCL) and interleukin 6 (IL-6) level in plasma (Table 2)
No significant differences were detected between SCL levels in the patients in the study group and the control group at individual time points
Summary
Chronic kidney disease (CKD) is classified, along with arterial hypertension, cardiovascular disorders, diabetes, and obesity, as one of the lifestyle diseases, which pose significant problems to public health [1]. It affects about 600 million individuals worldwide, including about 4 million. Patients undergoing hemodialysis therapy frequently experience chronic kidney disease-mineral bone disorders (CKD-MBD) and present with increased levels of inflammatory markers in blood [3]. Chronic kidney disease (CKD) is an important public health problem associated with, e.g., progressive renal insufficiency, bone mineral disorders, and increased inflammatory marker levels.
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