Abstract
Aim. To estimate an efficiency and tolerability of rilmenidine in hypertensive patients with different types of blood pressure (BP) daily profile – dipper and non-dipper. Methods. 23 patients with essential hypertension (EH), I-II stages, were included into the study. They were treated with rilmeneidine 1 mg daily during one month. Ambulatory BP monitoring (ABPM) and office BP measurements were made before and after the treatment. Based on ABPM results all patients were divided into two groups: with adequate decrease of BP at nighttime (dipper, D), and with insufficient decrease of BP at nighttime (non-dipper, ND). Results. One month rilmenidine monotherapy resulted in BP normalization in 52% of patients. Decrease in 24-hour BP, daytime and nighttime BP, burden with BP and BP variability during daytime was observed in both groups. A distinction in rilmenidine influence on BP daily index was revealed: initially normal BP daily index didn’t change in D group, while initially decreased BP daily index increased in ND group. Rilmenidine reduced the speed of morning BP rise in patients of ND group. Conclusion. Results of the study testify efficiency and satisfactory tolerability of monotherapy with rilmenidine 1 mg daily in patients with EH of I-II stages. For patients with insufficient decrease in BP during nighttime rilmenidine provides normalization of BP daily profile intensifying BP night decrease and reducing the speed of morning BP rise.
Highlights
Based on Ambulatory BP monitoring (ABPM) results all patients were divided into two groups: with adequate decrease of blood pressure (BP) at nighttime, and with insufficient decrease of BP at nighttime
One month rilmenidine monotherapy resulted in BP normalization in 52% of patients
Decrease in 24-hour BP, daytime and nighttime BP, burden with BP and BP variability during daytime was observed in both groups
Summary
Кафедра госпитальной терапии с курсом клинической фармакологии и семейной медицины СПбГМА им И.И. Кафедра госпитальной терапии с курсом клинической фармакологии и семейной медицины Санкт-Петербургской Государственной медицинской академии им. Изучить эффективность и переносимость терапии рилменидином у больных с различными типами суточного профиля артериального давления (АД) – dipper и non-dipper. 23 больным гипертонической болезнью (ГБ) I-II стадии проведено суточное мониторирование АД (СМАД) и офисное измерение АД на фоне терапии рилменидином в дозе 1 мг/сут. Результаты исследования свидетельствуют об эффективности и удовлетворительной переносимости рилменидина в дозе 1 мг/сут в качестве препарата для монотерапии ГБ I-II стадии. При этом у больных с недостаточным ночным снижением АД препарат способствует нормализации циркадного ритма АД, повышая степень его ночного снижения и уменьшая скорость утреннего подъема. Aim. To estimate an efficiency and tolerability of rilmenidine in hypertensive patients with different types of blood pressure (BP) daily profile – dipper and non-dipper
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