Assessment of relationship between contrast-induced nephropathy and left ventricular myocardial performance index in patients at risk for nephropathy

Abstract

Aim: Contrast induced nephropathy (CIN) is associated substantially with a risk of morbidity and mortality. The aim of this study was to assess the left ventricular myocardial performance assessed by ‘Tei index’ on the development of contrast induced nephropathy in patients underwent coronary angiography. Material and Methods: Study population consist of patients who underwent coronary angiography and/or percutaneous coronary intervention and baseline creatinine level 1 mg/dl above and/or having diabetes mellitus. 51 patient were included the study. Patients divided into two groups as CIN developed or not. CIN was defined as %25 and/or 0.5 mg/dl increase in basal serum creatinine levels after 48-72 hours exposure to contrast media. Conventional and tissue Doppler echocardiography was performed in all patients prior to angiography. Tei index was calculated from tissue Doppler echocardiography data. Results: Two groups were defined as CIN-developed group (n =13, 62.5 ± 6.8 ) and CIN-undeveloped (n=38, 62.4±9.6 )group. Except gender, there is no difference in demographic characteristics between the study groups. Left ventricular (LV) systolic function such as ejection fraction and tissue Doppler imaging Sm and basic LV diastolic function (E/A, Em/Am, DT) parameters were found to be similar in both groups. Tissue Doppler-derived Tei index values did not differ significantly between the two groups (0.42 ± 0.09 vs 0.46 ± 0.12, p = 0.25). Conclusion: The Tei index is inadequate for predicting the risk of developing nephropathy in patients at risk for contrast induced nephropathy with preserved ejection fraction.