Abstract
The purpose is to estimate the content of pro- and anti-inflammatory cytokines (IL-1 , IL-8, IL-10, MCP-1, ICAM-1, VEGF) in the tear liquid of patients with advanced proliferative diabetic retinopathy (PDR) and complicated primary cataract after phacoemulsification and IOL implantation performed simultaneously with vitreoretinal surgery vs. vitreoretinal surgery alone. Material and methods . 34 patients with PDR and complicated primary cataract were divided into two groups. Group 1 received a two-phase surgical procedure: (a) vitreoretinal surgery (VRS) with silicone oil tamponade followed by (b) phacoemulsification surgery, IOL implantation and silicone oil removal. Group 2 was subjected to (a) phacoemulsification simultaneously with vitreoretinal surgery and silicone oil tamponade and (b) silicone oil removal from the vitreous cavity. Both groups had their tear liquid samples examined before the surgery and on the 2 nd day after the 1 st phase. Results . Group 2 revealed a 2 to 2.5 times higher concentration of IL-8, MCP-1 and ICAM-1 as compared to Group 1. Conclusion . Increased concentrations of IL-8, MCP-1, and ICAM-1 in the tear after phacoemulsification surgery and IOL implantation coupled with vitreoretinal surgery as compared to vitreoretinal surgery alone requires additional research of the role played by the inflammatory component in the pathogenesis of postsurgical complications in advanced PDR patients.
Highlights
Ключевые слова: цитокины; пролиферативная диабетическая ретинопатия; витреоретинальная хирургия; факоэмульсификация катаракты Конфликт интересов: отсутствует
The purpose is to estimate the content of pro- and anti-inflammatory cytokines (IL-1, IL-8, IL-10, MCP-1, ICAM-1, VEGF) in the tear liquid of patients with advanced proliferative diabetic retinopathy (PDR) and complicated primary cataract after phacoemulsification and IOL implantation performed simultaneously with vitreoretinal surgery vs. vitreoretinal surgery alone
Material and methods. 34 patients with PDR and complicated primary cataract were divided into two groups
Summary
Increased concentrations of IL-8, MCP-1, and ICAM-1 in the tear after phacoemulsification surgery and IOL implantation coupled with vitreoretinal surgery as compared to vitreoretinal surgery alone requires additional research of the role played by the inflammatory component in the pathogenesis of postsurgical complications in advanced PDR patients. В настоящее время не вызывает сомнений, что витреоретинальная хирургия (ВРХ) является золотым стандартом хирургического лечения далеко зашедшей стадии пролиферативной диабетической ретинопатии (ПДР) [1]. Вто же время исследование и анализ содержания уровня про- и противовоспалительных цитокинов в слезной жидкости (СЖ) у пациентов с далеко зашедшей ПДР и осложненной начальной катарактой при одновременном выполнении ФЭК с имплантацией ИОЛ и ВРХ в сравнении с просто ВРХ практически не проводились. ЦЕЛЬ работы — изучить содержание про- и противоспалительных цитокинов (IL-1 , IL-8, IL-10, MCP-1, ICAM-1, VEGF) в СЖ у пациентов с далеко зашедшей стадией ПДР и осложненной начальной катарактой при одновременном выполнении ФЭК с имплантацией ИОЛ и ВРХ в сравнении с просто ВРХ. Критерии включения: наличие далеко зашедшей стадии ПДР и осложненной начальной катаракты; сахарный диабет (СД) II типа в стадии компенсации/субкомпенсации (целевое значение HbA1c < 7,5%); пациенты, которым в ходе ВРХ вводили силиконовое масло (СМ).
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