ASSESSMENT OF POTENTIAL HAZARD OF NICKEL OXIDE NANOPARTICLES

Abstract

Examination and evaluation of physical and chemical parameters of nickel oxide powder (Nickel (II) oxide, product number 637130) have shown that the substance of the complex physical and chemical properties, such as size, shape and surface area of the particles relates to nanotechnology products. According to the analysis of the annotated scientific literature sources it has been found out that nickel oxide nanoparticles were able to interact with cell membranes, proteins, DNA, and affect on the proteomic and metabolomic profile, accumulate in cells, tissues and organs, have a cytotoxic effect, possess transforming activity and carcinogenic effect. The analysis of the potential environmental impacts of nickel oxide nanoparticles has shown that it can be attributed to large-capacity industrial products, and therefore there was a possibility of exposure of personnel in the workplace. Estimation of the potential dangers of nano-sized nickel oxide using the method of mathematical modeling has showen that the nano-sized nickel oxide had a high degree of potential danger. Confirmation of this is the calculated coefficient of danger (D) of the substance amounted to 1,825 with reliable degree of assessment of the available information. Obtained results are required for subsequent detailed assessment of the toxicity of nano-sized nickel oxide and ensure public safety.