Assessment of Potential Duo Out of Syzigium aromaticum L., Zingiber officinale and Ocimum basilicum L. Leaves Extract for Extermination of Clinical Pathogens

Pratik M Bezalwar

doi:10.4172/2157-7471.1000265

Abstract

In last three decades numbers of new antibiotics have produced, but clinical efficacy of these existing antibiotics is being threatened by the emergence of multi drug resistant pathogens. This has forced scientist to search for new antimicrobial substances from various sources like the medicinal plants. Scope of this study is to evaluate the potential duo of Syzigium aromaticum L., Zingiber Officinale and Ocimum basilicum L against clinical pathogens; E. coli, S. aureus, B. cereus and P. vulgaris. Well diffusion method was adopted to study antimicrobial properties. The maximum zone of inhibition is produced by Syzigium aromaticum than other extracts S. aureus (17 mm) followed by B. cereus and P. vulgaris. Duo of Syzigium aromaticum and Zingiber officinale shown to have maximum antimicrobial property against E. coli, S. aureus, B. cereus and P. vulgaris which is expressed to be a best duo of extract and it is more potent (25 mm) for B. cereus. Duo of Zingiber Officinale and Ocimum basilicum and Ocimum basilicum and Syzigium aromaticum was least effective but in conclusion combined action of these extract is more enhanced than the individual extract. Our study indicates that phytoconstituents in combination can act better than individual. Therefore, they can be used for preserving various foodstuffs against microbial spoilage and it can be incorporated into medications for topical antifungal or antibacterial therapy.

Highlights

Infectious diseases caused by pathogens; bacteria, fungi, viruses and parasites are still a major threat to public health in spite of tremendous progress in human medicines [1]
Syzigium aromaticum L., Zingiber officinale and Ocimum basilicum L. was collected from vegetable market of Bhandara district
For the first part of experiment were extract was tested; Extracts of Syzigium aromaticum L., Zingiber officinale and Ocimum basilicum L. against clinical isolates of E. coli, S. aureus, B. cereus and P. vulgaris, the maximum zone of inhibition is produced by Syzigium aromaticum than other extracts, and Syzigium aromaticum showed maximum zone of inhibition for S. aureus (17 mm) followed by B. cereus and P. vulgaris with zone of inhibition of 15 mm and showed least zone of inhibition of 11 mm whereas Ocimum basilicum extract have almost same inhibition property against all test organisms and least antimicrobial property exhibited by Zingiber officinale (Table 1)

Summary

Introduction

Infectious diseases caused by pathogens; bacteria, fungi, viruses and parasites are still a major threat to public health in spite of tremendous progress in human medicines [1]. Plants have been a rich source of bioactive compounds to treat many diseases. Medicinal plants produce a variety of compounds with known therapeutic properties which is been traditionally used [3]. All the medicines used were from natural source, especially from plants [4]. In recent times plants have been exploited for pharmaceutical and sanitary purpose. Extraction by hydrodistillation from aromatic plants, they contain a variety of volatile molecules such as terpenes and terpenoids, phenol-derived aromatic components, and aliphatic components [5]. Medicinal and aromatic plants are gift of nature, which is being used against various infectious diseases and other curative purpose. Very small of total percentage of plants species have been exploited and investigated for their curative potential and very few fraction is screened for phytochemistry [6]. Study over toxicity profile of most medicinal plants has not been evaluated totally but a strong belief of ayurveda accepted that plant derived medicines far safer than their synthetic medicine [8]

Methods

Discussion

Conclusion