Abstract
Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood. Genome-wide association studies (GWAS) have greatly contributed to the identification of single nucleotide polymorphisms (SNP) associated with PCa risk. Several GWAS identified 8q24 as one of the most significant PCa-associated regions. The aim of this study was to evaluate the association of SNP rs378854 at 8q24 with PCa risk in the Serbian population. The study population included 261 individuals diagnosed with PCa, 257 individuals diagnosed with benign prostatic hyperplasia (BPH) and 106 healthy controls. Data quality analysis yielded results showing deviations from Hardy-Weinberg equilibrium in groups of PCa patients and BPH patients as well as in the control group. There was no significant association between alleles and genotypes of the genetic variant rs378854 and PCa risk in the Serbian population.
Highlights
Prostate cancer (PCa) is the second most commonly diagnosed malignant disease among men, and the sixth leading cause of cancer-related death in the male population (Ferlay et al, 2010)
The study included 261 individuals diagnosed with PCa and 257 individuals diagnosed with benign prostatic hyperplasia (BPH), who provided peripheral blood samples, as well as 106 healthy individuals comprising the control group from whom buccal swabs were obtained
The genotyping of rs378854 was successful in the 106 control subjects, 257 patients with BPH and 261 patients with PCa
Summary
Prostate cancer (PCa) is the second most commonly diagnosed malignant disease among men, and the sixth leading cause of cancer-related death in the male population (Ferlay et al, 2010). The number of new cases of PCa diagnosed in the Serbian population showed a 65% increase in the period between 1999 and 2009, according to data obtained from central Serbia (Vukičević et al, 2002; Miljuš et al, 2011). During this period, PCa remained the third most common cancer among males in the Serbian population (Vukičević et al, 2002; Miljuš et al, 2011). The only known risk factors for developing PCa, besides increasing age, are ethnic background and positive family history, which are considered to reflect the underlying genetic factors involved in PCa etiology (Hsing and Chokkalingam, 2006)
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