Assessment of Plasma Lipid Profile among Sudanese Menopausal Women in Khartoum state-Sudan

Abstract

Postmenopausal women tend to have significant changes in lipid profile when compared with premenopausal women. Incidence of cardiovascular disease after menopause believed to occur due to changes in the plasma lipid levels. This study was conducted to estimate and compare serum levels of total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) among Sudanese pre and postmenopausal women. 94 participant women were enrolled in this cross-sectional study. 47 post-menopause women age 48 - 70 years and 47 pre-menopause women age 25-47 years. Estimation of serum lipid profile was carried out using Biosystems colorimetric methods and results statistics were computed by using SPSS. A significant increase in total cholesterol(TC), triglyceride, and LDL-c with a significant decrease in (HDL-c) level among postmenopausal women where found, when compared with pre-menopause women (P-value= <0.05). Total cholesterol and LDL-C level were observed significantly increased according to three interval time duration of menopausal onset (p=0.009 and p=0.034). A positive correlation was observed between the age of and total cholesterol levels in postmenopausal women (R=0.463, P-value =0.001). Study results revealed that postmenopausal status was associated with substantial changes in lipid profile that considered risk factors for cardiovascular disease in Sudanese women.