Abstract
BackgroundBone morphogenetic proteins (BMP) are multifunctional proteins. They work as cytokines regulating osteogenesis during fracture healing process. The objectives of this study were to assess changes in BMPs during fracture and their correlations to Fracture’s healing.MethodsCase-Control hospital–based study conducted from January 2018 to January 2019. Demographic data, anthropometric measurements, and blood samples were collected from patients and controls (18–65 years old). Plasma concentrations of selected BMPs and vitamin D were measured using quantitative enzyme linked immunosorbent assay (ELISA). SPSS version 25 was used to calculate frequencies, Pearson correlation tests, chi-square and unpaired t-test.ResultsSixty-five patients with fractures and Sixty-five controls were studied. Means of plasma concentrations were (TGFβ1 = 21.07 ng/ml ±8.49 and 19.8 ng/ml ±7.2) (BMP-2 = 76.3 pg/ml ± 156.6 and 55.5 ng/ml ± 127.9) (BMP-7 = 13.02 pg/ml ±43.5 and 64.6pg/ml ±250) (BMP-10 = 8.14 pg/ml ±12.7 and 5.48 pg/ml ±11.3) (Vitamin D mean was 24.94 ng/ml ±13.2 and 26.2 ng/ml ±11.6) in patients and controls, respectively. Forty-five subjects were enrolled into follow up study: 30 males, 15 females. Healing time mean was 4.13± 2.6 months. No significant correlation between BMP-2/BMP-7 with healing time.ConclusionsBMP-7 was significantly lowers in the plasma of patients that controls (P = 0.042). Low Vitamin D was observed among Sudanese participants.
Highlights
Bone morphogenetic proteins (BMPs) are multifunctional proteins secreted by macrophages and assist in bone development and fractures’ repair [1]
No significant correlation between BMP-2/BMP-7 with healing time
Low Vitamin D was observed among Sudanese participants
Summary
Bone morphogenetic proteins (BMPs) are multifunctional proteins secreted by macrophages and assist in bone development and fractures’ repair [1]. BMPs are growth factors that help generation of new osteocytes (osteoinductive). This is carried out by activation of specific membrane bound receptors [3]. BMP-2 functions as a stimulant of mesenchymal cells differentiation into osteoblasts [4]. Recent studies support the use of BMP-2 and BMP-7 in clinical trials [5], while others reported that BMP-2 and BMP-7 might not have a role on fracture healing [6]. Bone morphogenetic proteins (BMP) are multifunctional proteins. The objectives of this study were to assess changes in BMPs during fracture and their correlations to Fracture’s healing
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