Assessment of patterns of cognitive impairment in diabetic patients a retrospective case-control study

Abstract

Abstract:Background: Cognitive dysfunction is common complaints among diabetic patients their occurrence emanate a great topic during the illness, so our study aimed to examine the occurrence and the pattern of executive dysfunctions in patients with type 2 DM.Methods: 40 patients with type 2 diabetes mellitus matched with 40 control subjects by age, sex, and educational level. They were examined for executive functions by event-related potentials (P300) and executive functions battery Results: patients with type 2 DM showed significantly affected P300 regarding both latency and amplitude. When using the executive functions battery, it showed deficits in most of the executive function tests with a significant difference between cases and control groups. There was a significant relationship between poor cognitive scores in diabetic patients and P300. Also, a significant positive correlation detected between poor scores of cognitive function tests in diabetic patients and poor glycemic control detected byHbA1c.Conclusion: Type 2 diabetes is associated with accelerated cognitive decline and an increased risk of dementia, particularly in older individuals. Our findings suggest that surface-recorded ERPs and executive functions battery is useful for determining and follow up the changes in brain function associated with diabetes mellitus, appropriate management, and treatment of type 2 diabetes mellitus could prevent the onset and progression of mild cognitive impairment to dementia so executive function battery could be more beneficial and significant than P300 in the assessment of diabetes mellitus related cognitive impairment.