Assessment of Pattern of Antimicrobial Resistance in Patients (Heliobacter pylori Positive) of Dyspepsia

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Purpose:Heliobacter pylori eradication is successful in 80% to 90% of the cases. Heliobacter pylori eradication rate varies in different parts of the world. This may be related to the regional difference in anti-microbial resistance that affects the outcome of therapy. In present study, our aim is to assess the pattern of antimicrobial resistance in patients (helicobacter pylori positive) of dyspepsia. Methods: 60 cases (15–50 years), with history suggestive of dyspepsia more than 4 weeks duration were included. Each patient underwent upper GI Endoscopy and gastric biopsy for rapid urease test and culture. Isolated bacteria were analyzed for their levels of antibiotic susceptibility to Metronidazole, Tinidazole, Ornidazole, Furazolidone, Clarithromycin, Amoxycillin, Ciprofloxacin and Tetracycline. The pattern of single and multiple resistance were analyzed. Results: out of 60 cases rapid urease test was positive in 38 cases and culture was grown in 26 cases. The antibiotic resistance of helicobacter Pylori in culture positive cases showed, 84.6% resistant to Metronidazole, 38.5% to Tinidazole, 7.6% to Ornidazole, 32.8% to Amoxicillin, 3.8% to Tetracycline, 19.2% to Clarithromycin, 11.5% to furazolidone and 3.8% to Ciprofloxacin. Conclusion: Antimicrobial resistance of helicobacter pylori is rapidly changing in different geographical areas and needs to define the resistance pattern in particular geographical area. This will help to improve result of treatment.