Abstract

Objective To investigate the value of follicular sensitivity index (FSI) in evaluating ovarian response in patients receiving in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods This present retrospective cohort study included infertility women who choosed a long-term program to promote ovulation treatment, and underwent IVF/ICSI-embryo transfer (ET) from April 2009 to December 2015 in the Reproductive Center of the People’s Hospital of Northern Jiangsu Province. Totally 1354 oocyte retrieval cycles were included, the correlation was analyzed between factors such as FSI and the number of oocytes retrieved, and the patients were divided into three groups: low FSI group (n=452), medium FSI group (n=451) and high FSI group (n=451) according to the tertile method. The basic clinical characteristics, controlled ovarian hyperstimulaiton (COH) cycle data and laboratory data of the three groups were statistically analyzed. Results The total dosage of gonadotropin (Gn) used, body mass index (BMI), age, infertility duration and the number of oocytes retrievaled were negatively correlated. Follicular output rate (FORT), antral follicles count (AFC), FSI, preovulatory follicles (PFCs) and ovarian sensitivity index (OSI) were positively correlated with the number of oocytes retrieved. The differences among the three groups were statistically significant (P rFSI>rFORT. Infertility duration, age, BMI, basal FSH/LH ratio, basal prolactin (PRL) level, FSH starting dosage, total FSH dosage, human menopausal gonadotropin(hMG) dosage, duration of Gn used, total Gn dosage, the number of oocytes retrieved, OSI and FORT were statistically significant among the three groups (P<0.05). Conclusion FSI value has a certain correlation with ovarian reactivity, and patients with high FSI have high ovarian response. Key words: Follicular sensitivity index; Controlled ovarian hyperstimulation; Ovarian response

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