Assessment of Newly Diagnosed Celiac Disease Presented at Different Ages and its Relation to Nitrosative Stress and Lipid Peroxidation

Abstract

Background and objectives: The clinical presentations of celiac disease (CD) are remarkably various age dependent. Free radicals overproduction may implicate in pathogenesis of CD or its complications. This study aimed to assess newly diagnosed CD from the following points of view: clinical presentation, cardiac involvement and free radicals overproduction taking in consideration the age of diagnosis. Methods: This study designed as a cross sectional in cohort patients with newly diagnosed celiac disease.Patients presented with diarrhea responded to the gluten free diet and positive serological tests of CD were admitted in the study. Left ventricular function was assessed by measuring the ejection fraction (%) and the free radicals were assessed by measuring the serum NO and peroxynitrite (ONOO) as well as malondialdehyde (MDA), a biomarker of lipid peroxidation. Results: One hundred eighty two newly diagnosed CD patients (73males and 109 females) were studied. There were no significant differences in intestinal and extra intestinal clinical manifestations at any age ranged between 4 and 65 years. Ejection fraction of patients at any age of clinical presentation was within normal range of corresponding healthy subjects. Also the hematological indices and biochemical tests did not show significant variation regarding the age. Significant high serum MDA, NO and ONOO levels compared with healthy subjects' levels were observed. Interpretations and conclusions: There are no significant differences between child and adult CD regarding the clinical presentations, biochemical findings, cardiac assessment and overproduction of reactive oxygen and nitrogen. Nitrosative stress syndrome is associated with celiac disease at any age.