Assessment of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Iron Deficiency Anemia

Abstract

Background and Aim: The present study is undertaken to investigate and establish the alteration in the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in iron deficiency anemia patients and to elucidate the link between iron with immunity and hemostasis. Methods: Complete hemogram along with differential leucocyte count and platelet count was done in 100 untreated iron deficiency anemia patients, who are visiting/admitted to KIMS, OPD, Hubballi, using Automated analyzer (HP 120). Results: The results of the present study showed clearly that there is a significant increase (P<0.05) in neutrophil-lymphocyte ratio as well as platelet-lymphocyte ratio among moderate and severe anaemic patients compared to normal individuals. Moreover, this increase in the ratio is more evident as the severity of anemia is increased. Conclusion: The alteration in neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in these patients may be due to low levels of iron as iron has a vital role in proliferation of different blood cells, especially lymphocytes. Thus, the outcome of the present study may be suggestive of a probable link between iron and immunity.