Assessment of myostatin in obese males and females with and without fatty liver

Abstract

Abstract Objectives This study was carried out to assess myostatin levels in obese males and females with and without fatty liver. Methodology This is a comparative case control study was conducted in Ain Shams University hospital. Patients were divided into two groups. Group1: 40 obese patients of both sexes (20 of them with fatty liver and 20 without fatty liver) Group 2: 40 normal weight patients of both sexes (20 with fatty liver and 20 without) In this study we considered the serum concentration of myostatin seems to range from 7 to 32 ng/ml in the general population as in the literature All participating patients have to sign informed oral or written consent after through explanation of the purpose and procedure of the study. The current protocol is to be approved by the Ethical Committee of Internal Medicine Department and the Ethical Committee of Faculty of medicine Ain shams University. The collected data was be tabulated and statistically analyzed using SPSS program (Statistical Package for Social Sciences) software version 20.0 Descriptive statistics was done for numerical parametric data as mean+-SD (standard deviation) and minimum and maximum of the range and for numerical non parametric data The level of significance is taken at p value <0.050 is significant otherwise is non-significant. Results The body mass index (BMI) among the groups of patients is significantly associated with gender and the present or absent of fatty liver. Statistically significant with value (0.000) BMI is significantly associated with gender in the present or absent of fatty liver. Statistically significant with value 0.005 Very few report myostatin level less than the normal value 2/80 (2.5%), normal range was only 12/80 (15%) and those reported high range of myostatin were 66/80 (82.5%). The myostatin level is significantly associated the BMI. 95% CI of difference were between 103.25 to 233.9. Std. error of mean is 32.84. Statistically significant with value (0.000) where it is considered to be significant with value <0.05. Conclusion This study revealed the association between BMI, gender and elevated myostatin at level of statistically significant value. The majority of the study population reported high range of myostatin were in about 82.5% the range was above the normal values. A large scale, multicentre study to provide strong evidence was recommended.