Abstract
BackgroundAssessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI). Methods and resultsPigs underwent resting [15O]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analysis of MBF showed similar area under the curve (AUC) of 0.85, 0.86, and 0.90 with relative MBF, PTF, and PTI for the detection of viable myocardium defined as infarct volume fraction of < 75%. Cut-off values of relative MBF of ≥ 67% and PTF of ≥ 66% resulted in accuracies of 90% and 81%, respectively. ConclusionsOur results indicate that resting MBF, PTF, and PTI based on [15O]water PET perfusion imaging are useful for the assessment of myocardial viability.
Highlights
Myocardium of patients with coronary artery disease (CAD) and left-ventricle (LV) dysfunction often contains a mixture of ischemic, but viable and irreversibly injured, non-viable tissue.[1]
Our results indicate that resting myocardial blood flow (MBF), perfusable tissue fraction (PTF), and perfusable tissue index (PTI) based on [15O]water positron emission tomography (PET) perfusion imaging are useful for the assessment of myocardial viability. (J Nucl Cardiol 2021;28:1271–80.)
We evaluated the performance of resting MBF, PTF, and PTI by [15O]water PET in the detection of myocardial infarction (MI) and viability in comparison with histology in a pig model
Summary
Myocardium of patients with coronary artery disease (CAD) and left-ventricle (LV) dysfunction often contains a mixture of ischemic, but viable and irreversibly injured, non-viable tissue.[1]. Differentiation between viable and non-viable myocardium by [15O]water PET is based on the concepts of reduced fraction of tissue that is capable of rapidly exchanging water[10,11,12,13,14] as well as low and heterogeneous MBF11,15-17 in the injured myocardial regions. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI)
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