Abstract
Left main stem (LMS) disease is found in approximately 5% of patients with stable angina and in approximately 7% of patients presenting with an acute myocardial infarction. Accurate assessment of the degree of left main stem stenosis has important prognostic and therapeutic implications. Clinically, angiographic LMS stenosis of 50% or more is considered significant. However, it is not known how accurately myocardial perfusion imaging detects LMS disease at this severity threshold.
Highlights
Left main stem (LMS) disease is found in approximately 5% of patients with stable angina and in approximately 7% of patients presenting with an acute myocardial infarction
To measure myocardial blood flow by CMR in patients with LMS stenosis of more than 50% on quantitative angiography in the CEMARC study
To correlate hyperaemic myocardial blood flow (MBF) and blood flow reserve between territories supplied by the LMS and remote territories
Summary
Left main stem (LMS) disease is found in approximately 5% of patients with stable angina and in approximately 7% of patients presenting with an acute myocardial infarction. Accurate assessment of the degree of left main stem stenosis has important prognostic and therapeutic implications. Angiographic LMS stenosis of 50% or more is considered significant. It is not known how accurately myocardial perfusion imaging detects LMS disease at this severity threshold. To measure myocardial blood flow by CMR in patients with LMS stenosis of more than 50% on quantitative angiography in the CEMARC study (a large prospective evaluation of CMR against SPECT and coronary angiography[1]). 2. To correlate hyperaemic myocardial blood flow (MBF) and blood flow reserve between territories supplied by the LMS and remote territories
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