Abstract
Diffusion tensor tractography--a new method of magnetic resonance imaging, that allows to visualize the pathways of the brain and to study their structural-functional state. The authors investigated the changes in motor and sensory pathways of brain in children with cerebral palsy using routine magnetic resonance imaging and diffusion-tensor tractography. The main group consisted of 26 patients with various forms of cerebral palsy and the comparison group was 25 people with normal psychomotor development (aged 2 to 6 years) and MR-picture of the brain. Magnetic resonance imaging was performed on the scanner with the induction of a magnetic field of 1,5 Tesla. Coefficients of fractional anisotropy and average diffusion coefficient estimated in regions of the brain containing the motor and sensory pathways: precentral gyrus, posterior limb of the internal capsule, thalamus, posterior thalamic radiation and corpus callosum. Statistically significant differences (p < 0.05) values of fractional anisotropy and average diffusion coefficient in patients with cerebral palsy in relation to the comparison group. All investigated regions, the coefficients of fractional anisotropy in children with cerebral palsy were significantly lower, and the average diffusion coefficient, respectively, higher. These changes indicate a lower degree of ordering of the white matter tracts associated with damage and subsequent development of gliosis of varying severity in children with cerebral palsy. It is shown that microstructural damage localized in both motor and sensory tracts that plays a leading role in the development of the clinical picture of cerebral palsy.
Highlights
Diffusion tensor tractography — a new method of magnetic resonance imaging, that allows to visualize the pathways of the brain and to study their structural-functional state
The authors investigated the changes in motor and sensory pathways of brain in children with cerebral palsy using routine magnetic resonance imaging and diffusion-tensor tractography
Coefficients of fractional anisotropy and average diffusion coefficient estimated in regions of the brain containing the motor and sensory pathways: precentral gyrus, posterior limb of the internal capsule, thalamus, posterior thalamic radiation and corpus callosum
Summary
Диффузионно-тензорная трактография — новая методика магнитно-резонансной томографии, позволяющая визуализировать проводящие пути головного мозга и изучать их структурно-функциональное состояние. Цель исследования: установить особенности изменений моторных и сенсорных путей головного мозга у детей с детским церебральным параличом с помощью рутинной магнитно-резонансной томографии и диффузионно-тензорной трактографии. Методы: основную группу составили 26 пациентов в возрасте от 2 до 6 лет с различными формами детского церебрального паралича, группу сравнения — 25 человек с нормальным психомоторным развитием и МР-картиной головного мозга. Результаты: установлены достоверные различия (p
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