Assessment of migration regularity of phthalates from food packaging materials.

Jing-Min Liu,Ji-Chao Liu,Yan Zhang,Ze He,Ning Zhao,Shi-Wen Lv,Li-Jun Chen,Fei-Er Yang,Shuo Wang,Chun-Yang Li

doi:10.1002/fsn3.1863

Abstract

Phthalate acid esters (PAEs) are one of the essential plastic additives which may lead to plenty of harmful effects, including reproductive toxicity, teratogenicity, and carcinogenicity. Increasing attention has been paid to the migration of plasticizer. In this article, the disposable plastic lunch boxes were taken as the research object. The result showed that dibutyl phthalate (DBP) and diisobutyl phthalate (DIBP) have been mainly found, whose content was 1.5 mg/kg and 2.4 mg/kg, respectively. The LOD was 2 ng/g, and LOQ was 6.7 ng/g. We further investigated the migration of PAEs into the simulated liquid at different temperature conditions. Then, the linear fitting performing by first‐order kinetic migration model revealed that the lower the polarity of the simulated liquid, the larger the rate constant K 1 and initial release rate V 0. The higher the temperature, the bigger the K 1 and V 0.

Highlights

In recent years, plasticizers have been commonly used in industrial production because they could enhance the flexibility and improve the properties of plastics (Gao, Zhu, & Luo, 2018; Hubinger, 2010)
It is a general term for a wide range of chemical compounds, such as benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), dimethyl phthalate (DMP), di-2-(ethylhexyl) phthalate (DEHP), and diisobutyl phthalate (DIBP)
X: migration amount of the target analyte in mg/kg; C: concentration of the target analyte obtained by gas chromatography-mass spectrometry (GC-MS), in units of mg/L; V: volume of the soaking liquid, the unit is L; S: contact area of the sample with the migration device, the unit is dm2; 6: EU Directive 2004/19/EC specifies 1 mg/kg = 6 mg/dm2; The final migration experiment results are expressed in terms of mobility, that is, the percentage of migration, the ratio of the content

Summary

| INTRODUCTION

Plasticizers have been commonly used in industrial production because they could enhance the flexibility and improve the properties of plastics (Gao, Zhu, & Luo, 2018; Hubinger, 2010). PAEs are small molecules that only bound to plastic matrix by hydrogen bond or van der Waals force That is why they may migrate from packaging materials especially in oil- or fat-containing food (Kiani et al, 2018; Net, Sempere, Delmont, Paluselli, & Ouddane, 2015; Rastkari, Jeddi, Yunesian, & Ahmadkhaniha, 2018). Albert et al (Guart, Bono-Blay, Borrell, & Lacorte, 2014) studied the effects of different plastics on the migration of PAEs during the storage of bottled water in Spain, whereas, due to the considerable differences in food matrices, the variety of packaging materials, and the complicated migration process, the development of migration experiment has been greatly restricted. The linear fitting results were obtained based on the migration amounts of targets and first-order kinetic migration model

| MATERIALS AND METHODS

| RESULTS AND DISCUSSION

| CONCLUSIONS