Assessment of Micro-Albuminuria and Renal Artery Resistance Index in Psoriatic Patients

Abstract

Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Micro albuminuria is considered to be maker of glomular disease and can be used to predict diabetic or hypertensive nephropathy. The aim of the study was to evaluate micro-albuminuria and renal artery resistance index in psoriatic patients as an early diagnostic marker of kidney affection. Methods: This was a cross sectional casecontrol study, included 84 subjects classified into two groups: Patient group: 50 patients complaining of psoriasis. Control group: 34 apparently healthy of matched age and sex as control grouP.Each patient was subjected to full history taking, and complete clinical examination, Clinical assessment of psoriatic lesions is done to to determine the distribution, clinical variants and the extent of psoriasis. Assessment of psoriasis grade was done using PASI score. All studied subjects were tested for: Measuring microalbumuria in urine by ELISA. Results and conclusion: On comparing both groups of patients and controls in this study there was a significant increase of the mean level of microalbuminuria in psoriatic patients compared with controls. There was a positive correlation between the level of microalbuminuria and severity of psoriasis (PASI score) with a significant value. Microalbuminuria and renal artery resistance were elevated in psoriatic patients and has positive correlation with disease severity and may have a role in disease pathophysiology.